Histochemical Studies on Copper Metabolism

Studies on Copper Metabolism*

The results of studies on certain enzymes, hemin chromoproteins, and iron and copper in the tissues of normal, copper-deficient, and iron-deficient swine are reported in this paper. It has been suggested that the enzymes cytochrome oxidase (l-3), uricase (4), tyrosinase (5), plasma polyphenol oxidase (coeruloplasmin) (6), glutathione oxidase (7), and butyryl coenzyme A dehydrogenase (8) either ...

Studies on copper metabolism. XXXI. Erythrocyte copper.

Studies on Copper Metabolism. Xix

Ferrokinetic studies were performed in three copper-deficient swine and the results have been compared with similar studies in 18 normal pigs. The mean value for the plasma iron turnover rate in the deficient swine was 1.76 mg./kg. day; for the red cell iron incorporation rate, 1.24 mg./kg. day; for the red cell iron turnover rate, 1.18 mg./kg. day; for the red cell life span, 13 days. Correspo...

Studies on copper metabolism. IV. The influence of copper on the absorption of iron.

In a previous paper in this series (l), evidence was presented that the absorption of iron from the gastrointestinal tract of swine deficient in copper is markedly reduced. This conclusion rests, in part, on the observation that in copper-deficient pigs fed the same quantity of either natural or radioiron for the same period of time as litter mate controls there was less iron absorbed, natural ...

Histochemical Studies on Hydrolytic Enzyme Activities

Histochemical observations were carried out on various hydrolytic enzymes in the spontaneous mammary carcinoma of C3H-strain mice. Alkaline phosphatase activity was observed in the luminal border of the tubular structure and in the periluminal surface, which showed a cystic dilatation in ducts and papillae. Capillaries in the stroma showed a high enzymatic activity. Acid phosphatase activity wa...